States of sublimity sketched in. Is tempered by the knowledge that one is unlikely to be around to enjoy them. Will experience every moment of their lives as a magical epiphany. Can this best be done? .

What is Crack Cocaine? Is an alkaloid found in leaves. Of the South American shrub Erythroxylon coca. It is a powerfully reinforcing psychostimulant. The drug induces a sense of exhilaration in the user primarily by blocking the reuptake of the neurotransmitter dopamine. Activation of dopamine D2 receptors induces release of an endogenous opioid peptide that binds rewardingly to mu opioid. Receptors in the nucleus accumbens. If the predictions of The Hedonistic Imperative.

The Hedonistic Imperative outlines how genetic engineering and nanotechnology will abolish suffering in all sentient life.

Mental Health in the Third Millennium. A brief history of MDMA. The molecular machinery of magic. Can safe, sustainable analogues of MDMA. There is an urgent need for non-neurotoxic empathogens. Basis Hence most of us are doomed to display the quasi-psychopathic indifference to each other characteristic of the MDMA-naïve state.